Study on the Screening Test of Genotoxicity to Volatile and Insoluble Compounds such as Halon Replacements Using Mammalian Cell Culture.
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概要
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A new method for the screening test of genotoxicity to volatile and insoluble compounds such as halon replacements using mammalian cell culture was developed. The method was composed of two systems; a gas handling system producing sample gas of a particular concentration from original material in a Tedlor bag, and a gas exposure system on the cells in a glass culture bottle by incubation for one day. A positive control, Bromochloromethane, exposed by this gas exposure system induced sister-chromatid exchanges (SCEs) as a dose depended manner within concentrations of 0.5-2.0%. Among 8 halon-related compounds tested by the system, 7 samples did not induce significant levels of SCEs while Halon 1301 alone gave weakly positive result, i.e., apporoximately twice of the control SCEs. It was suggested that this gas exposure system could use as a screening test for genotoxicity using mammalian cell culture of volatile and insoluble compounds such as halon replacements.
- 日本環境化学会の論文
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