Mutagenic and Mass Spectrometric Characterization of Oxygen Analogs(P=O) derivatized from Organothiophosphorus Pesticides.
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概要
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Organothiophosphorus (P=S type) pesticides in aqueous solution have been shown to be converted to their oxygen analogs (P=O type) when the solutions were treated with chlorine or ozone. Ten P=O compounds were, therefore, prepared for their mass spectrometric and mutagenic studies.<BR>The mass spectra of P=O compounds [phosphates: (RO) <SUB>2</SUB>P (=O) -OR, phosphoamidoates: (RO) <SUB>2</SUB>P (=O) -NHR] were complex and α-cleavage (P: OR, P: NHR), β-cleavage (PO: R, PNH: R) and numerous rearrangements occurred. For phosphates in which the R moiety was aliphatic (i.e., malaoxon) and for phosphoamidoates (i.e., butamifos-oxon and isofenphos-oxon), the molecular ion peaks were in general relatively weak. On the other hand, when the R moiety was aromatic, intense molecular ion peaks were observed.<BR>Among 10 P=O compounds tested for mutagenicity in bacterial reversion-assay systems with 2 strains (TA98 and TA100) of<I>S. typhimurium</I>in the absence and presence of rat liver homogenate (S9 mix), EPN-oxon, isophenfos-oxon, malaoxon and paraoxon were found to be mutagenic. Chlorpyrifos-oxon, daizoxon and fenitro-oxon also exhibited weak mutagenicity. For butamif os-oxon, isoxa-oxon and tolclofos-methyl-oxon, no mutagenic effects were detected in the reversion assay systems.
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日本環境化学会 | 論文
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