Mutagenicity Detection of Volatile N-Nitrosamines.
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概要
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A new gas exposure system that measures the mutagenicity of volatile nitrosamines was evaluated. The examinations used to determine the test conditions in this system, using N-nitrosodiethylamine (NDEA) under S9mix conditions, showed the greatest mutagenicity in the<I>E. coli</I>WP2uvrA/pKM101 strain, next in the<I>S. typhimurium</I>TA100 strain, and no mutagenicity in the<I>S. typhimurium</I>TA98 strain. The variation coefficients obtained from this system were shown to be comparatively small (3.9-10.8%) .<BR>The mutagenic activity of the four nitroso compounds were compared in three assays using the WP2uvrA/pKM101 strain with the S9mix. The order of mutagenic activity obtained was as follows: N-nitrosodi-<I>n</I>-butylamine>N-nitrosodi-<I>n</I>-propylamine > N-nitrosodiethylamine>N-nitrosodimethylamine. The mutagenic detectability with increasing molecular weight of the nitrosamines was as follows: gas exposure system>preincubation assay>plate incorporation assay.
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