Mutagenicity of Chlorination Products of Benzophenone and Its Derivatives

概要

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Six kinds of benzophenone and its derivatives were suspended in water and chlorinated with sodium hypochlorite at pH4, 7, and 10. Chlorination products were extracted with dichloromethane and concentrated. Concentrated samples were subjected to mutagenicity tests and GC/MS analysis. Benzophenone (BP) and 2-hydroxy-4-octyloxybenzophenone (HOBP) did not consume chlorine. Contrary, 2, 4-dihydroxybenzophenone (DHBP) and 2, 2'-dihydroxy-4-methoxybenzophenone (DHMBP) consumed almost all of chlorine. Several chlorinated compounds were detected by GC/MS analysis in the chlorination products, except BP Many of them were chlorobenzophenones and chlorophenolic compounds.<BR>Mutagenicity of chlorinated products was tested by Ames assay using<I>Salmonella typhimurium</I>TA98 and TA100. Chlorination products of DHBP, DHMBP, and 2, 2'-dihydroxy-4, 4'-dimethoxybenzophenone (DHDMBP) showed relatively high mutagenicity. On the other hands, HOBP did not show mutagenicity. BP showed highly growth inhibition to TA98 and TA100. Generally, the mutagenicity of Chlorination products of benzophenones was metabolisminactive, and increased at low pH. The mutagenic potencies did not depend on the amounts of the major products. Thus, to evaluate the safety of chlorination products of landfill leachates properly, not only chemical analysis but also bio-assay technique should be needed.
日本環境化学会の論文