Development of Analytical Method for Determining Trace Amounts of BPA in Urine Samples and Estimation of Exposure to BPA.
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概要
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We have developed a reliable analytical method for determining trace amounts of bisphenol A (BPA), a suspected endocrine disruptor, in urine samples by use of GC/MS so that daily exposure of human bodies to BPA can be estimated. We administered BPA-d<SUB>16</SUB> (100μg) to volunteers in order to conduct an excretion experiment and found that the BPA was absorbed quickly through the digestive tract and excreted mainly as a glucuronide conjugate into urine, in an amount of almost 100 % in 24 hours. The results suggest that determining the BPA content of urine samples enables estimation of the exposure to BPA.<BR>The results of our analysis of urine from adults show that the average total BPA concentration was 0.82 ng/ml (0.14-5.47 ng/ml, n=91) and that the average free BPA concentration was 0.08 ng/ml (0.01-0.27 ng/ml, n=11) . Also, from a determination of whole-day urine samples, the exposure to BPA was estimated to be 1.68 μg/day (0.48-4.5 μg/day, n=22) on the average.
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