Comparison of Methods for Estimating Limit of Detection in GC/HRMS for Dioxins.

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Five methods for estimating the limit of detection are compared with regard to the estimates of LOD and reproducibility of the LOD estimates in GC/HRMS for dioxins. The following methods are taken: 1. LOD based on repetition: Three times SD of area measurements (area SD, n = 5) ; Three times SD of height measurements (height SD, n=5) ; 2. LOD based on S/N: Six times SD of baseline noise (baseline SD) ; Six fifths of envelope of baseline (baseline range) ; 3. LOD based on probability theory of signal and noise (FUMI theory) . The LOD estimates obtained from the above methods, except the height SD, are comparable to each other. The reproducibility of the LOD estimates is ca. 30 % RSD for the area SD, height SD and baseline range, ca. 20 % RSD for baseline SD and ca. 15 % RSD for the FUMI theory. The FUMI theory is concluded to be the best choice from the viewpoints of statistical reliability and practicality.
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