Clinical Application of 113Sn-113mIn Cow (Fourth Report):Radioisotope Renal Angiography Using New Preparation 113mInFe-DTPA Ascorbic Acid

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Our aim was to synthesize 113mIn compound for kidney scanning. High concentration of 113mInFe-DTPA ascorbic acid was found in the kidney after injection of rat tail vein and this 113mIn compound was very rapidly excreted into urine in man. With the 113mInFe-DTPA ascorbic acid, scintiphoto of the kidney was successfully made using the scintillation camera, although kidney scintillation scanning was in vain by the conventional rectilinear scanner. Six to twelve mCi of 113mIn was rapidly injected intravenously and serial five to eight seconds exposure scintiphotos of the kidney were obtained. This method is the so-called radioisotope renal angiography. By radioisotope angiography with 113mInFe-DTPA ascorbic acid it can be determined whether a renal mass is vascular or not, that is, neoplasm or cyst, because a tumor stain (or a tumor blush) is obtained in a vascular neoplasm in the same as X-ray contrast renal angiography. Preparing procedure of 113mInFe-DTPA ascorbic acid is following. To the 113mIn in dilute HC1 eluted from the cow, Fe+++ as the chloride and DTPA (diethyl triamine pentaacetic acid) was added. We then added ascorbic acid to the mixture before neutralization in order to decrease amount of DTPA and prevent particle formation of Fe (OH) 3. Terminal sterilization of the product by 0.45 μ millipore filter is possible because of absence of particle.
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