EFFECT OF ROXITHROMYCIN ON SUPEROXIDE GENERATION BY POLYMORPHONECLEAR LEUKOCYTES FROM CHILDREN WITH BRONCHIAL ASTHMA

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The effect of roxithromycin (RXM) on superoxide (O2-) generation was studied in peripheral polymorphonuclear leukocytes (PMN) from children with bronchial asthma. The O2- generation activity was investigated using methoxy-cypiridina luciferin analog (MCLA), a specific chemiluminescence (CL) probe for O2- RXM suppressed the ability of O2- generation at 1×10-5M, the concentration of clinical use. The level of suppression was different among stimulants to PMN.
日本小児アレルギー学会の論文