INVESTIGATION CONCERNING THE MOST SUITABLE METHOD OF METERED DOSE INHALER (MDI) OF β-STIMULANT:INHALATION FLOW RATE AND LUNG VOLUMES PRIOR TO INHALATION

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We examined clinical symptoms and the changes of the MEFV curve under the conditions of different inhalation flow rates in patients with childhood asthma who inhaled β-stimulant with MDI. A total of 18 subjects with an average age of 11.6 years; 12 boys and 6 girls were studied. The result was that every case indicated a good rate of improvement after inhalation, and a deep slow 3-seconds inhalation of the metered-dose aerosol showed higher tendency to improve the pulmonary function than a deep fast 1-second inhalation.In the third trial, we examined the effects of variations in inhalation volume on the changes of the MEFV curve in asthmatic children who inhaled β-stimulant with MDI. A total of 20 subjects with an average age of 11.4 years; 14 boys and 6 girls were studied. The result was that every case indicated good improvement, and an inhaling aerosol from the point of FRC showed higher tendency to improve the pulmonary function than that of RV.
日本小児アレルギー学会の論文