THE PROPHYLACTIC EFFECT OF KETOTIFEN AGAINST THE ONSET OF ASTHMA IN INFANTS WITH ATOPIC DERMATITIS

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We evaluated the prophylactic effect of ketotifen against the onset of asthma in seventy-three infants with moderate or severe atopic dermatitis without history of asthma. Thirty-three infants (male 17, female 16, mean age 10.8months) did not receive ketotifen or other antiallergic drugs (control group). Fourty infants (male 21, female 19, mean age 13.7 months) received 0.8mg/day ketotifen for one year (ketotifen group). Both groups were followed for one year to evaluate the first asthmatic attack and the changes of serum IgE and RAST (mite, egg white, cow milk).During this one year study, mild asthmatic attacks were observed in 21 infants (63.3%), moderate or severe asthmatic attacks were observed in 5 infants (15.2%) of the control group. Mild asthmatic attacks were observed in 16 infants (43.2%), moderate or severe asthmatic attacks were observed in 4 infants (10.8%) of the ketotifen group. The occurrence of first asthmatic attack was significantly lower in ketotifen group (P<0.05).During this one year study, serum IgE elevated in 33 infants (69.7%) of the control group, in 10 infants (32.3%) of the ketotifen group (P<0.001). There were no significant differences in those two groups in the changes of RAST (mite, egg white, cow milk).
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