STUDY OF THE RELATIONSHIP BETWEEN NASAL SMEARS FROM CHILDREN AND SERUM ANTI-HOUSE-DUST MITE SPECIFIC IgG

概要

論文の詳細を見る
In order to understand the function of specific IgG, nasal secretion samples from 212 children with allergic rhinitis were studied to determine the relationship between cells in nasal smears and serum specific IgG and IgE antibodies. The relationship between eosinophils in nasal smears and serum specific IgE and IgG antibodies showed a strong correlation. The relationship between the appearance of mast cells in nasal smears and serum specific IgE also showed a strong correlation, but the relationship between these and serum specific IgG did not show a significant correlation. The appearance of neutrophils in nasal smears coincided with the presence of eosinophils in nasal smears. When the nasal provocation test was studied, the level of histamines in nasal secretions of patients, who were positive for serum anti-house-dust Mite specific IgG, was higher than in those who were negative, and changes in NCF in patients with neutrophils in their nasal smears were higher than those in patients without neutrophils. These findings support the view that, in allergic rhinitis, elements such as neutrophils and chemical mediators, eosinophils and serum specific IgG, mast cells and serum specific IgE, interfere and mix in a very complex manner, creating a more complicated understanding of the status of the disease.
日本小児アレルギー学会の論文