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We measured specific IgE antibodies to ovalbumin (OVA), ovomucoid (OVM) and boiled milk (BM) with CAP-FEIA® specific IgE in 74 sera from children suspected hen's egg and/or cow's milk allergy. These results were compared to those of hen's egg white (EW) and cow's milk (CM) and the results of clinical histories of allergic symptoms after ingestion of heated hen's egg and CM.The frequencies of positive specific IgE antibodies to EW, OVA, OVM, CM and BM were 72%, 73%, 58%, 36%, and 22%, respectively. Significant correlation of specific IgE titers among egg related allergens (r=0.77-0.92), and between cow's milk related allergens (r=0.97) were observed. The results of specific IgE antibody titers to OVA were similar to those obtained with EW. The clear clinical histories of allergic symptom after ingestion of heated hen's egg were obtained from 44 children. Eleven of 13 (84.6%) children with negative specific IgE to both OVA and OVM had no symptoms. All the children with positive to OVA and negative to OVM had no symptoms (n=9). Eight of 20 (40%) children with positive to these two had allergic reaction. One of 2 children with border (class 1) to OVA and positive to OVM had allergic reaction. Thus specific IgE to OVM was more specific than specific IgE to OVA and EW. The apparent histories of allergic symptom after ingestion of heated cow's milk were also obtained from 56 children. Only one of 27 (3.7%) children with negative to both CM and BM had allergic reaction. Two of 21 (9.5%) children with positive to these two had allergic reaction. Only one of 9 (11.1%) children with positive to CM and negative to BM had allergic reaction. Therefore specific IgE to BM was more specific than specific IgE to CM.These results suggest that specific IgE antibody to OVM and BM might be useful marker for diagnosis of hen's egg or cow's milk allergy and monitoring of elimination therapy of these foods. However, reactivity or tolerance to heated hen's egg and cow's milk proteins are not fully explained by these two tests.
- 日本小児アレルギー学会の論文
日本小児アレルギー学会 | 論文
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