Intensive Short-Term Chemotherapy for B Cell Lymphoma and B Cell Acute Lymphoblastic Leukemia in Children.
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概要
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We treated 18 children, of whom 9 had B-cell lymphoma (B-NHL) and the other 9 had B-cell acute lymphoblastic leukemia (B-ALL), with an intensive short-term chemotherapy regimen "B-88 protocol". This protocol consisted of high-dose fractionated cyclophosphamide and high-dose methotrexate. Sixteen of 18 patients (89%) achieved complete remission (CR), two of whom relapsed within 5 months. One patient who had completed chemotherapy developed a second leukemia. However, the other 13 patients were maintained their initial CR, and their event-free survival, caluculated by Kaplan-Meier's method, was 72% overall (mean follow-up of 51 months), 58% for stage IV-NHL/ALL, 80% for stage III-NHL and 100% for stage I/II-NHL. We conclude that the B-88 protocol is effective for B-NHL/B-ALL and more than a half of such patients may be curable by treatment with chemotherapy alone. We designed a new "B-93 protocol" involving a lower dose and a shorter duration of chemotherapy for the favorable stage I/II-NHL, and the introduction of high-dose cytosine arabinoside for stage III/IV-NHL/ALL in an attempt to achieve a better prognosis.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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