High-Dose Multiple Drug Chemotherapy Followed by Autologous Bone Marrow Transplantation in a Child with Glioblastoma Multiforme.
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A 9-year-old girl with glioblastoma multiforme was treated with surgical resection (95%) and high-dose multiple drug chemotherapy followed by autologous bone marrow transplantation. Nimustine, etoposide, vincristine, methotrexate and carboplatin were administrated by intravenous injection and procarbazine was administrated orally for 7 days. The nucleated marrow cells, 0.85 × 10<SUP>8</SUP> cells/kg (0.32×10<SUP>5</SUP> CFU-GM/kg), were infused. The patient recieved granulocyte colony-stimulating factor from day 1 to day 22. The absolute neutrophil count reached 500/μ1 on day 13 and the platelet count reached 50, 000/μ1 on day 28. Red blood cell transfusion and platelet transfusion were performed on days 3 and 4, respectively. Febrile episodes were observed during periods of neutropenia for 18 days. Reversible toxicities to heart and kidney were observed.She has been in complete remission for 3 years and 1 month. We suggest this treatment method is useful for patients with GBM.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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