Aquired Monosomy 7 in a Case of MDS Developed after Chemotherapy who Had Undergone Surgery for Ependymoblastoma.
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Here we report a case of myelo-dysplastic syndrome (MDS) with monosomy 7, which occured after chemotherapy. The patient was a 5-year-old girl who had undergone surgery for ependymoblastoma at the age of 1 year and 5 months followed by chemotherapy for 2 years. However, 36 months after the start of chemotherapy, pancytopenia developed and blast cells were found in the peripheral blood. Bone marrow aspirate revealed hypocellularity with about 30% blast cells lacking peroxidase stain. Chromosome analysis of the blast cells revealed them to be 45, XX, -7. Therefore, MDS with monosomy 7 developed after chemotherapy. Treatment with prednisolone and a low-dose cytosine arabinoside regimen was started. The blast cells were decreased in peripheral blood. At that time Granulocyte colony-stimulating factor was administered to her, subsequently the leukocyte count increased, accompanied by a more rapid increase of blasts. She died because of sepsis.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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