Study on Ectoenzyme Activity of Biphenotype Leukemia and Effect of Its Inhibitor.
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概要
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Biphenotype leukemia has been considered to be one of the therapy-resistant leukemia that express ectoenzymes on their surface. We investigated the activity of neutral endopeptidase (CD 10) and aminopeptidase N (CD 13 : APN) in acute lymphoblastic leukemia (ALL), biphenotype ALL and acute non-lymphoblastic leukemia (ANLL) cell lines. Biphenotype cell had both activities that mean to have ALL and ANLL character. The enzyme inhibitors could inhibit these activities in a dose dependent manner. Especially, ubenimex, a specific inhibitor of APN, inhibited APN activity and cell growth under the concentration of clinical use. These results suggest that ubenimex has some clinical benefits on CD13-positive ALL-like ANLL.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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