Proliferation and Dissemination of Leukemic Cells In Vivo. SCID Mice as a Human Leukemia Model.:SCID Mice as a Human Leukemia Model

概要

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To analyze the complex mechanism of growth of leukemic cells In vivo, the immunodeficient (SCID) mouse model will provide a powerful new approach to characterize, human leukemia. Most human leukemic cells grow by interacting with stromal or accessory cells In vivo and in vitro. Cytokines produced by these supporting cells or by the leukemic cells stimulate the proliferation of leukemia in paracrine or autocrine fashion, respectively. The contact of leukemic cells to extracellular matrix is one of the main pathways to disseminate to peripheral organs. Normal hematopoietic cells engrafted in SCID mice grow and differentiate in BM by the support of several growth factors. The ALL cell lines and cells from patients grow and disseminate in the SCID organs, and the growth pattern of leukemic cells in SCID mice correlates with the course of disease in each patient. However, most AML cells grow in SCID organs with the presence of several growth factors. The proliferation of leukemic cells in SCID mice can be prevented by immunotoxins and anticancer drugs, suggesting that these drugs will be effective to treat the patients with refractory leukemia. The SCID mouse model will provide useful information to analyze the mechanism of growth of leukemic cells In vivo.
特定非営利活動法人　日本小児血液・がん学会の論文