Combination of Chemotherapy and Buffy Coat Transfusions from the Marrow Donor in the Treatment for Relapsed Chronic Myelogenous Leukemia in Blastic Crisis after Allogeneic Bone Marrow Transplantation.
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概要
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A 12-year-old boy underwent allogeneic bone marrow transplantation (BMT) from his HLA indentical sister for chronic.myelogenous leukemia (CML) in the first chronic phase after 6 weeks of interferon-alpha therapy. Three months after BMT, the patient was found to have a hematologic relapse in blastic crisis, which was unsuccessfully treated with various multiagent combination chemotherapies. To overcome the refractory disease, viable buffy coat cells from the marrow donor were transfused to the patient after an intensive chemotherapy. Subsequently, a complete remission associated with disappearance of Ph<SUP>1</SUP> chromosome was attained. Four months later, the patient received second BMT from the same donor. A complete remission obtained in this case could be due to the following factors : (1) the donor lymphocytes may have killed the Ph<SUP>1</SUP> positive clone as a graft-versus-leukemia effect, and (2) peripheral blood stem cells may have played a role in hematological recovery after intensive chemotherapy. This kind of combination therapy is considered to be worth attempting for patients with relapsed CML after allogeneic BMT.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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