Hematopoietic Progenitor Cells in Umbilical Cord Blood.
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概要
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We collected umbilical cord blood at the delivery of a baby girl whose elder sister was suffering from a severe type of juvenile chronic myelogenous leukemia and for whom there were no human leukocyte antigen (HLA) -matched relative donors available. Blood from the umbilical cord and placenta was obtained by needle aspiration immediately after the delivery, frozen in a programmed freezer without red blood cell depletion, and preserved in liquid nitrogen. The cryopreserved cord blood contained 0.79 × 10<SUP>8</SUP> nucleated cells/patient's body weight (kg), 2.12 × 10<SUP>4</SUP> burst-forming uniterythroid (BFU-E) /kg and 2.41 × 10<SUP>4</SUP> colony-forming unit-granulocyte-macrophage (CFU-GM) /kg. These numbers were within the reported range associated with successful allogeneic umbilical cord blood transplants. Because HLA typing showed 2 locus mismatched, the baby was not appropriate for a bone marrow donor. Thus, the possibility exists that umbilical cord blood may be a potential source of pluripotential hematopoietic stem cells for allogeneic bone marrow transplantation instead of harvesting bone marrow cells from an HLA-identical sibling in the neonatal period.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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