Treatments and the Prognosis in Childhood Aplastic Anemia.
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概要
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We evaluated the treatments of aplastic anemia in children with some immunosuppressive agents such as prednisolone (Pred), anabolic steroid (AS), high-dose methylprednisolone (HDMP), antilymphocyte globulin (ALG; Ahlbulin, Green Cross Co., Osaka, Japan), cyclosporin A (CyA) and 7-globulin. Thirteen children with aplastic anemia (6 severe, 7 moderate) were treated in our hospital between 1977 to 1991. Eleven were male and 2 were female and aged from 1 year to 15 years and 5 months (median of 8 years and 6 months). Five cases were treated with combination of Pred and AS. Three of them were effective and achieved complete remission. HDMP was effective in 25% of 8 cases and CyA in 50% of 2 cases. But both ALG and high dose γ-globulin had no hematologic response. Six died, three of them died of infection and the others died of intracranial bleeding. The survival rate was 42.2%. We conclude that it is not enough to achieve the complete remission by the immunosuppressive therapy alone, so bone marrow transplantation will be necessary for the improvement of the therapeutic results of the childhood aplastic anemia.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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