Bone Marrow Failure Caused by Human Parvovirus B19 in a Leukemia Patient on Maintenance Chemotherapy.
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概要
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A 7-year-old boy had acute lymphoblastic leukemia. Remission was inducted and maintained with therapy of the 1 1 th S2 protocol proposed by Tokyo Children's Leukemia Study Group (TCLSG). During maintenance therapy at 3 years of disease onset, severe anemia and thrombocytopenia developed. The bone marrow was hypoplastic. Chemotherapy was discontinued and packed erythrocyte and platelet transfusions were performed. Bone marrow hypoplasia caused by human parvovirus B19 (B19) was diagnosed by detection of B19 DNA and subsequently IgM and IgG antibodies to B19 in the serum. With the appearance of antibodies to B19, hematological findings were improved 1 month after the clinical manifestation of anemia and thrombocytepenia without therapy for B19. These findings suggested that B19 infection can lead to bone marrow failure in immunocompromised patients, such as those who are on an antileukemic drug therapy.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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