A Report of a Boy with AML with 3p-, 8q-, 10p+, 17q+ Presenting with Facial Diplegia.
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A case of AML with rare chromosomal abnormality, presenting with facial diplegia is reported. A two-year-old boy was referred to our hospital because of the left facial nerve palsy following transient right facial nerve palsy. The leukocyte count of peripheral blood was 1.38×10<SUP>4</SUP>/μl, 24% of which were myeloid blast cells (FAB, M2 type). Bone marrow was occupied with 78.5% blasts cytochemically positive for myeloperoxidase. Cytogenetic analysis showed them to be 3p<SUP>-</SUP>, 8q<SUP>-</SUP> 10p<SUP>+</SUP>, 17q<SUP>+</SUP> with or without-Y; surface markers, CD 13 and CD 19, were simultaneously expressed on the same blast cells by two-color flow cytometry. Lumbar puncture revealed initial CNS leukemia ; brain CT and MRI revealed chloromas in the right temporalis and posterior fossa and leukemic infiltration and inflammation of mastoid. The facial nerve palsy and abnormal pulse site in MRI disappeared after induction chemotherapy and cranial irradiation. He has been in remission for 10 months after diagnosis. MR studies are likely to be useful in diagnosis and assessment of treatment of masoitditis due to leukemic infiltration.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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