Early Onset of Congestive Heart Failure in an Infant Treated with Adriamycin for Malignant Histiocytosis.
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概要
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An infant treated with Adriamycin (ADR) for malignant histiocytosis (MH) developed congestive heart failure (CHF) at 6 months after 8 ADR courses (total dose : 280 mg/m2 body surface). The CHF improved transiently, exacerbated 3 months later, and persisted subacutely with remarkable elevation of serum CPK and liver origin enzymes. In the active stage of MH, serum interferon-γ and interleukin-6 levels were elevated. When the CHF occurred, these levels remained within normal, indicating that the patient was in remission for MH. Further studies will be required in many cases to define that the cytokines exert some roles in the early development of ADR cardiomyopathy.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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