Production of interleukin-1 in children with acute lymphoblastic leukemia.
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The production of interleu kin-1 (IL-1) was examined in children with acute lymphoblastic leukemia (ALL) in order to assess the peripheral blood monocyte function. Peripheral blood mononuclear cells (PB-MNC) obtained from ALL children were stimulated with OK432 or autologous ALL cells. IL-1 in culture supernatant was quantitated with bioassay using peanut agglutinin-negative mouse thymocytes. Sequential study showed that IL-1 production following OK432 stimulation reached the peak within 24 hours. Major producing cells in peripheral blood were plastic-adherent cells which were shown to be monocytes morphologically and cytochemically. Most of IL-1 was released into culture supernatant, whereas solubilized fraction of OK432-stimulated PB-MNC contained little IL-1 activity. The production of IL-1 was well maintained in ALL cases both on chemotherapy and off chemotherapy. There was no significant difference in terms of IL-1 production between ALL patients and healthy subjects. Instead, inter-patient variation was remarkable in the group of patients on chemotherapy. In mixed cultures with autologous ALL cells, significant IL-1 production was observed in one out of 10 cases, suggesting that the specific anti-tumor immunity might be established.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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