Immunological and cytogenetic characteristics of infant acute leukemias.
スポンサーリンク
概要
- 論文の詳細を見る
Twenty-three infants (under one year old) with acute leukemia were studied for immunological and cytogenetic characteristics. Thirteen patients were diagnosed as acute lymphoblastic leukemia (ALL) and ten were acute non-lymphocytic leukemia (ANLL). In 11 cases among the 13 ALL patients, the leukemic blasts did not express CD10 (J5). Two out of 11 patients had leukemic cells with concomitant expression of CD13 (MY7) and. CD19 (B4) antigens, and they eventually underwent remarkable changes in morphology from (FAB) -L1 to M5b at relapse. In four other cases, the leukemic cells disclosed additional expression of CD13, CD14 (MY4), and CD33 (MY9) antigens after short-term culture, although the blasts of the remaining five cases were not altered phenotypically by the treatment, and stayed only HLA-DR and CD19 positive. Ten ANLL cases were classified as 6 monocytic or myelomonocytic and 4 megakaryocytic leukemias. Cytogenetic analyses were carried out in 15 cases. Translocations involving 11q 23 site were identified in 8 of 9 ALL and 3 of 6 ANLL patients. Two megakaryocytic leukemia cells showed trisomy of No. 21 chromosome. These observations imply that acute leukemia in infancy is a distinctly heterogeneous disease in phenotypical respects, but that in the majority of cases, except megakaryocytic leukemia, biphenotypic features were demonstrated. The leukemic cells of infant leukemia may be of stem cell origin with a potential for lymphoid, myeloid, and conclusively monocytic differentiation.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma