The Study of Combination Chemotherapy with MTX and Ara-C for Leukemia
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概要
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Conventionally, multidrug therapies have been applied extensively for the purpose of increasing efficacy of antitumor agents. To obtain favorable therapeutic results it is necessary to know the interaction among the drugs. Methotrexate (MTX) and 1-β-D-arabinofuranosyl cytosine (Ara-C) are representative drugs for leukemia therapy. Although some inconsistency is seen among the reports of various authors, in many papers these two drugs have been reported to act antagonistically when used at the same time. In the present study, we investigated interaction between MTX and Ara-C using CCRF-CEM cells already established. MTX and Ara-C were cytotoxic against CCRF-CEM cells in both a concentration-dependent and time dependent manner in respective use. When MTX and Ara-C were administered simultaneously or administration of Ara-C preceded that of MTX, colony count showed even an increasing tendency when compared with administration of Ara-C alone in methylcellulose culture. Under these conditions both drugs are considered to interact antagonistically.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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