Growth Curve and Hematological Prognosis after Bone Marrow Transplantation in Children with Severe Aplastic Anemia

概要

論文の詳細を見る
As of June 30, 1987, 45 children with severe aplastic anemia had received bone marrow transplantation in Japan, and 40 of them were alive. Quality of life and residual abnormality of these 40 children were studied. Among the 40, growth curves were available for 29 children. Four of the 20 boys and one of the 9 girls had body height below the 3rd percentile (-2 standard deviation). Relationship between the type of pretreatment of bone marrow transplantation and growth retardation was not clear. Chronic GVHD (graft versus host disease) was seen in 12 out of 37 children who received allogeneic bone marrow. However, only one had severe chronic GVHD with Karnofsky performance score 30%, and the others were above 90%. In 15 children, OKT4/0K8 ratio was below 0.8. However, no significant relationship was noted between the ratio and the time interval after the bone marrow transplantation. All patients were hematologically normal. Three of the children, including one syngeneic transplantation, experienced rejection of transplanted bone marrow. Two of them had "taken" the second bone marrow with the pretreatment of cyclophosphamide and total body irradiation. In the other patient, the bone marrow of his own recovered after rejection of transplanted bone marrow.
特定非営利活動法人　日本小児血液・がん学会の論文