Acute GVHD and Thrombotic Microangiopathy (TMA) after Stem Cell Transplantation
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概要
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Thrombotic microangiopathy (TMA) after stem cell transplantation is characterized by arteriolar thrombi associated with intimal damage of the vessel walls and by ischemic and hemorrhagic organ damage. Recently, intestinal TMA has been introduced and the discrimination of TMA from acute GVHD has been getting obscure because of the lack of diagnostic criteria for TMA, and moreover because of the definition of acute GVHD without the recognition of TMA. The risk factors for TMA are the immunosuppressive drugs, such as FK 506 and cyclosporine, unrelated donors, HLA-mismatched related donors, ABO-incompatibility and veno-occlusive disease. TMA is difficult to treat once established. Successful treatment for TMA by diminishing immunosuppressive drugs after early diagnosis of TMA with colonoscopic biopsies is warranted.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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