Induction of Immune Tolerance in Patients with Hemophilia A and Inhibitors after Changing the Factor VIII from a Different Origin.
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We report 2 cases with severe hemophilia A that developed inhibitors and acquired immune tolerance to them after replacing a different origin for factor VIII. In the first case, a regular infusion of recombinant factor VIII (r-FVIII) was applied after a diagnosis of hemophilia A. The inhibitor appeared within the first year after the start of regular infusions of r-FVIII. The titer of the inhibitor had decreased following immune tolerance induction (ITI) therapy with plasma-derived factor VIII (pd-FVIII). On the other hand, in the second case, the inhibitor appeared after regular infusions of pd-FVIII. The infusions of pd-FVIII had been stopped and the inhibitor titer declined ; the infusions of r-FVIII had been started and the inhibitor disappeared. These cases indicate that ITI is possible even when factor VIII of a different origin is used.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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