Intermittent Extramedullary Relapse on Breast and Uterus after Allogeneic Bone Marrow Transplantation in a Child with Acute Myelogenous Leukemia.
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We had a rare case of a 13-year-old girl with an acute myelogenous leukemia (FAB : M2) of 8 ; 21 chromosome translocation who had an intermittent extramedullary relapse on breast and uterus. She received allogeneic bone marrow transplantation (allo-BMT) from her HLA-matched sibling at first remission. Twenty-three months after the allo-BMT, she had an extramedullary relapse on her breast. The second remission was induced by reinduction chemotherapy and donor leukocyte infusion (DLI) therapy. But 37 months after the allo-BMT, she had a second relapse on her extramedullary site of the uterus. We started reinduction chemotherapy to do a second allo-BMT. Unfortunately, she died 68 days after her last admission because of an uncontrollable infection. We chose reinduction chemotherapy and DLI at the first extramedullary relapse, but she could not sustain long-term remission. For this reason, therapy at the first relapse may have been insufficient. In conclusion, we believe that the extramedullary relapse, as in our case, needs more aggressive therapy, which may include a second BMT.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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