Study on Prognosis and Prognostic Factor in Children with Aplastic Anemia, Experienced for Past 3 Decades.
スポンサーリンク
概要
- 論文の詳細を見る
To determine whether or not recent advances in therapy, except for the use of bone marrow transplantation (BMT), contribute to improve the prognosis of aplastic anemia, we retrospectively investigated the survival rate, remission rate and prognostic factors of 33 children with aplastic anemia hospitalized in the Pediatric Department of Hirosaki University School of Medicine. The study covers 3 decades, from 1965 to 1994, and cases were divided to 3 groups according to the chronological period of onset (group I, 1965-1974 ; group II, 1975-1984 ; group III, 1985-1994). For the average of all cases, the survival rate was 69.7% and remission rate was 51.5%. The survival rate was obviously increased in the cases of severe aplastic anemia in group III as compared to group I and group II. However, the remission rate for severe aplastic anemia did not change, rather the remission rate decreased in mild and moderate cases with each passing decade. These results indicate that recent treatments excluding BMT, including immunotherapy and cytokine administration, are not always so favorable as therapies for aplastic anemia. The highest mortality rate was found in the age group under 3 years; so an important prognostic factor was considered to be the disease severity and the age at onset.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma