Successful Treatment of Ecthyma Gangrenosum in a Neonate with Congenital Neutropenia using Recombinant Human Granulocyte Colony Stimulating Factor.
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概要
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Using the recombinant human granulocyte colony stimulating factor (rhG-CSF), ecthyma gangrenosum in a neonate with congenital neutropenia was successfully treated. On day 4 of life, the male baby had perianal deep erythema, which rapidly developed to necrotic demarcated ulcerations caused by <I>Pseudomonas aeruginosa</I>. He had severe neutropenia (200/, μl), and was treated with rhG-CSF in combination with intensive antibiotics. After the administration of rhG-CSF, the number of neutrophils was elevated and the perianal ecthyma resolved. Bone marrow (under the treatment of rhG-CSF) revealed hypoplasia of neutrophils and their precursors. Antineutrophil antibodies were not detected in his serum. The maintenance therapy with rhG-CSF (10→25→40μg/day) was performed and the number of neutrophils was maintained 300-500/μl. Daily administration of rhG-CSF was altered to intermittent administration, but he has been free from severe infectious diseases. His mother also had had moderate neutropenia (200-500/μl) for a long time without severe infections. The congenital neutropenia in the patient is probably classified as familial benign chronic neutropenia, although he had severe infections during the newborn period. rhG-CSF was also effective for prophylaxis of severe infections in this case.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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