ヒトヘルペス科ウイルス感染-1-癌患者におけるEBV感染と免疫

概要

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Human herpesviruses have been known to be reactivated from latent infection in immunosuppressed individuals. To asses the immunity, antibodies to human herpesviruses (VZV, HSV, CMV and EBV) were measured in patients with gastointestinal cancer and normal persons ranging from 40 to 80in age.<BR>CF antibodies to herpesviruses except for EBV were negative in normal persons below the age of 60 and cancer patients aged 60 and over. The CF antibody titer higher than 1: 64 occurred only in young cancer patients and older normal persons.<BR>The titer of VCA antibody to EBV ranged from 1: 40 to 1: 160 in more than 80% of normal persons and was higher than 1: 640 in less then 7%. The ratio those with antibody negative or below 1: 40 increased with the age. In contrast, the titer was higher than 1: 320 in 70% of the cancer patients, and the antibody was negative in none of them. In addition, the low titer occurred only in less than 5%. The rate of patients having higher VCA antibody titers increased with age, and the titer was high in more than 50% of patients in the 8th decade.<BR>In cancer patients, the higher the VCA antibody titer was, the less number of mature B cells, target cells of EBV, and the B cell functions were observed. This suggests that reactivation of EBV inhosts bearing carcinomas results in a fall of production of the specific antibody.
日本感染症学会の論文