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The relation between conductivity and fixed charge density (FCD) in the articular cartilage has been investigated. A measuring system of the resistivity of the articular cartilage has been developed on the basis of the four-point probe technique. The system was designed so as to measure the resistivity as a function of depth from the articular surface. There was a good agreement with the theoretical relation as shown herewith. The conductivity κ of the articular cartilage equilibrated in a pH 7.4 Ringer's solution was constant in all zones with a value of 6 to 10×10S/cm. On the contrary, κ of the articular cartilage equilibrated in distilled water varied distinctly, being low in the superficial zone (about 0.7×10S/cm) and high in the middle to deep zone (about 3×10S/cm). This was almost the same variation as that of the FCD which was measured by the tracer cation method, and a linear correlation between κ and FCD was found. The correlation coefficient was 0.88.As an application of the measuring system, compressive strain was applied to the articular cartilage equilibrated in distilled water and the resistivity was measured. From the change of the resistivity vs. depth relation with the strain, it was found that the superficial to middle zones were more compressible than the deep to calcified zone up to 20% strain.
一般社団法人日本生体医工学会の論文