Metabolism of Fenitrothion in Goats

概要

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The lactating Japanese Sannen goats were treated orally with 14C-ring labeled fenitrothion [O, O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate, Sumithion®] at 0.5mg/kg/day for 7 days. At 1 day after treatment, no residues of intact fenitrothion were found in the organs and tissues, and a little amount of aminofenitrothion was detected in digestive tracts (rumen, omasus and large intestine). The radiocarbon disappeared rapidly thereafter. The administered radiocarbon was essentially quantitatively excreted during a week post-treatment period; 50% of the dose were recovered in urine, 44% in feces, and 0.1% in milk with a maximum of 0.011ppm equivalent to the parent compound. The remaining radioactivity was further excreted, although gradually. The major metabolites in urine, feces and milk were O, O-dimethyl O-(3-methyl-4-aminophenyl) phosphorothioate (aminofenitrothion) and O-methyl-O-hydrogen O-(3-methyl-4-acetylaminophenyl) phosphate, and O, O-dimethyl O-(3-methyl-4-sulfo aminophenyl) phosphorothioate (N-sulfo aminofenitrothion), respectively. No intact fenitrothion nor fenitrooxon was found in milk, urine and feces.
日本農薬学会の論文