Two Cases of Rhabdomyosarcoma of the Paranasal Sinus using VAIA Chemotherapy and Operation

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• We reported two cases of rhabdomyosarcoma of the paranasal sinus using VAIA chemotherapy and operation. In spite of using same chemotherapy, they took contrary course. The first case (30-year-old male) of rhabdomyosarcoma of left paranasal sinus (T4N2bM0) with left neck lymph nodes swelling underwent left radical neck dissection, superfacial parotidectomy, and ethomoid sinus dissection using Killian's method after 4 course of VAIA chemotherapy. But tumor was reccurenced to his neck and axial area, and finally occurred hepatic and pancreatic metastasis. He died 4 months after his operation. The second case (57-year-old male) of rhabdomyosarcoma of left paranasal sinus (T4NOM0) underwent left radical neck dissection, superfacial parotidectomy, and total maxillectomy (including eye ball resection) with opened craniofacial area after 4 course of VAIA chemotherapy. Reconstruction of this patient's dead space was used rectum abdominal free flap. He now lives 1 year 11 months after initial presentation with tumor free. We concluded that the patient who had neck lymph node metastasis at initial presentation should be taken intensive chemotherapy, because it's prognosis would be poor even if we had done operation. These patients may have a possibility of distant metastasis more than N0 patients. The patient who had no neck lymph node metastasis should be done more extended operation after using VAIA for 4 course. After then adj uvant VAC chemotherapy is need. The chemotherapy of VAIA is one of the effective chemotherapy for rhabdomyosarcoma.

• 特定非営利活動法人 日本頭頸部外科学会の論文

特定非営利活動法人 日本頭頸部外科学会 | 論文

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