Oita International Electrocardiology Symposium 2000 "Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside":Block of Na exchangers on ischemia induced arrhythmias
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Cariporide and KB-R9032, new Na-H exchange (NHE) subtype 1 inhibitors, have antiarrhythmic effects on canine coronary ischemia and reperfusion induced arrhythmias, which might be induced by intracellular Ca overload following myocardial ischemia. These favorable antiarrhythmic effects on coronary ischemia and reperfusion occurred without changes in the blood pressure, heart rate and ECG parameters. Such antiarrhythmic and antifibrillatory effects were specific for myocardial ischemia related arrhythmias, namely they did not show such antiarrhythmic effects on digitalis or adrenaline induced arrhythmias, the mechanisms of which are also thought to be due to intracellular Ca overload. A new selective Na/Ca exchange inhibitor, KBR7943, was proved to be a reverse mode inhibitor, but failed to show antiarrhythmic effects on the canine coronary ischemia and reperfusion induced arrhythmias.
- 特定非営利活動法人 日本心電学会の論文
特定非営利活動法人 日本心電学会 | 論文
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