Studies on the Tuberculin Reactivity of Tuberculin-Active Peptide1

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概要

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• A comparative study of the tuberculin potency and reactivity to TAP and PPD-S was made in humans and guinea pigs. A comparison of reactions elicited by TAP and PPD-S was made in two groups of guinea pigs previously inoculated with killed bacilli or with living bacilli. The tuberculin reactions produced by TAP and PPD-S in human beings was studied in school children from rural districts. These children were divided randomly into three groups and each group was given a different amount of TAP and PPD-S. The results obtained are as follows: (1) While relative potency of TAP was relatively much weaker than PPD-S in guinea pigs sensitized with tubercle bacilli, in human beings the tuberculin potency of TAP was approximately 1/2 or 1/3 that of PPD-S. (2) There was a marked difference in the tuberculin reactivity to TAP and PPD-S between guinea pigs immunized with killed bacilli and guinea pigs immunized with living bacilli.

• 財団法人 学会誌刊行センターの論文

著者

• Kataoka Tetsuo

  Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos

• Asami Nozomu

  Department Of Animal Husbandry Faculty Of Agriculture Tohoku University

• YAMAMURA Yuichi

  Department of Microbiology, Shizuoka College of Pharmacy

• SOMEYA SHIRO

  Department of Microbiology, The Institute of Public Health

• ASAMI Nozomu

  Department of Microbiology, Institute of Public Health

• KOYAMA Kenjiro

  Department of Microbiology, Institute of Public Health

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