Monoclonal Antibodies Recognizing Atherosclerotic Lesions in WHHL Rabbit
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概要
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It is well known that cholesterol ester accumulate in atherosclerotic arterial wall. In this paper, two monoclonal antibodies against lipid laden cells (FCR1a/201F) and extracellular matrix where lipid deposited (EMRIa/212D) are discussed.<BR>FCRIa/201F recognized lipid laden cells from both Watanabe-Heritable Hyperlipidemic rabbit and human atherosclerotic aorta. The cells probably both macrophages and modified smooth muscle cells are transformed to lipid laden cells during accumulation of cholesterol ester. EMRIa/212D recognized extracellular matrix where lipid deposited. Antigenic substances against this antibody must be glycoprotein, the epitope of which is sialic acid.<BR>These evidences obtained from experimental atherosclerotis (WHHL rabbit) may help understanding how lipid accumulate in arterial wall in human patient.
- 公益社団法人 日本実験動物学会の論文
公益社団法人 日本実験動物学会 | 論文
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