The effect of enalapril and sairei-to on survival-time for the rat with subtotal nephrectomy.
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The effect of an angiotensin-converting enzyme inhibitor, enalapril, and a Japanese medicinal plant named sairei-to, after administration either alone or in combination, on survival-time due to the protection of proteinuria and the preserving of renal function, was studied in the rat with subtotal nephrectomy. Resection of 2/3 of the left kidney and removal of the right kidney was performed in 28 male Wister rats (220-250g). The rats were divided into four groups:(1)control (without sairei-to or enalapril);(2)with sairei-to(2.5%in rat chow); (3)with enalapril (50mg/l in drinking water);and(4)the combination of enalapril and sairei-to. The actual survival-times until natural death after renal ablation in these four groups were 92±3, 128±8, 199±19, and 194±13 days, respectively. Urinary protein excretion and renal function were markedly protected in the enalapril-treated rats. Urinary endothelin excretion was also attenuated in enalapril-treated rats. Statistical analysis revealed the absence of benefits with sairei-to alone or in combination treatment. In conclusion, enalapril provides protection of proteinuria and preserves renal function, which results in a longer survival-time in the rats having subtotal nephrectomy. However, sairei-to does not show such beneficial effects.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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