Importance of HbA1c to Detect Diabetes Mellitus in Health Examination
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概要
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The national program of health evaluation and promotion is supposed to start in 2008. The program mentions to detect impaired glucose metabolism, i.e. firstly either fasting blood glucose (FBS) or HbA<SUB>1</SUB>c may be chosen, secondly if both FBS and HbA<SUB>1</SUB>c are measured, value of FBS takes precedence over HbA<SUB>1</SUB>c. Using our data in 2006, we examined the policy.<BR>Among the subjects whose FBS and HbA<SUB>1</SUB>c were checked simultaneously, 410 were referred to medical facilities for further examination or treatment according to a certain criteria, i.e. FBS of 126 mg/d<I>l</I> or higher and/or HbA<I>l</I>c of 6.1% or higher.<BR>The results of further or re-examination were sent back in 235 subjects (57.3%) . Among 108 subjects with FBS of 126 mg/d<I>l</I> or higher, 86 (79.6%) were diagnosed as diabetes mellitus (DM) . On the other hand, 172 (83.1%) were diagnosed as DM among 207 subjects with HbA<SUB>1</SUB>c of 6.1% or higher. Diagnostic efficiency of DM is not significantly different between FBS and HbA<SUB>1</SUB>c.<BR>In 235 subjects, only FBS, or only HbA<SUB>1</SUB>c or both FBS and HbA<SUB>1</SUB>c meat the criteria were 28 (FBS group), 127 (HbA<SUB>1</SUB>c group), and 80 (FBS + HbA<SUB>1</SUB>c group), respectively.<BR>A hundred and eighty three subjects were diagnosed as DM, 11 in FBS group (39.3%), 97 in HbA<SUB>1</SUB>c group (76.4%), and 75 in FBS + HbA<SUB>1</SUB>c group (93.7%) . Diagnostic efficiency of DM in HbA<SUB>1</SUB>c group was better than in FBS group (<I>p</I> < 0.005), and the efficiency in FBS + HbA<SUB>1</SUB>c group was also better than both in FBS group and in HbA<SUB>1</SUB>c group (<I>p</I> < 0.005, respectively) . If FBS only is examined to detect DM, 97 (53.0%) out of 183 subjects with DM must have been missed. The cost-effectiveness analysis also suggests the usefulness to examine HbA<SUB>1</SUB>c.<BR>Our data suggest that HbA<SUB>1</SUB>c is indispensable to detect DM in health examination, and also both FBS and HbA<SUB>1</SUB>c should be measured in the health examination program.
- 一般社団法人 日本総合健診医学会の論文
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