Tissue concentration and clinical efficacy of imipenem/Cilastatin sodium in the field of oral surgery.

概要

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Imipenem/Cilastatin sodium (IPM/CS ; Tienam®), A combination (1 : 1) of a new carbapenem antibiotic with an inhibitor of renal dipeptidase has a broad spectrum of activity against aerobic and anaerobic bacteria. We measured the tissue and serum concentration of IPM in 23 patients with the disease of oral cavity undergoing surgical resection. Clinical efficacy of IPM/CS used for several infections and postoperative chemoprophylaxis were also evaluated. 1) Mean serum levels of IPM were 23.3μg/ml after one hour of the administration and 14.7μg/ml after two hours, and the tissue concentrations were 4.79μg/ml and 3.35μg/ml, respectively. These results indicate that IPM levels are high enough in situ and effectiveness. 2) IPM/CS was administered in 3 patients with oral surgery infections, and the clinical responses were good in 2 cases, poor in 1 case. 3) IPM/CS is a useful antibiotic for the postoperative chemoprophylaxis in the field of oral surgery. 4) Side effects of vomiting and nausea were recorded in 4 cases, but they were mild and disappeared soon without treatment.
日本歯科薬物療法学会の論文