Clinical evaluation of a new non-steroid anti-inflammatory agent, Pranoprofen (Niflan) in treatment of ambulantory postoperative cases in oral surgery.

概要

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A new non-steroid anti-inflammatory agent, Pranoprofen (Niflan®), was administered postoperatively to 30 cases which received various ambulantory surgical operations in the field of oral surgery at our department between December 1984 and April 1985. The clinical researches were done and the following results were obtained. 1) The performed operations in this study were composed of complicated exodontias, removal of benign tumors and cysts, making a small window on the anterior wall of the sinus with chronic sinusitis and others. 2) The patients took capsules with 75 mg of Pranoprofen for three times a day, i.e. 225 mg a day for 3 days to 10 days. 3) The results were evaluated into four steps from the view point of inhibiting the postoperative inflammation from"excellent"till"no effect."The results of the whole cases showed that the excellent inhibition was accounted for 14 cases or 47% of 30 cases, the middle inhibition 6 cases or 20%, the slight inhibition and no effect each 5 cases or 16.5%. 4) Side effects were recorded on none of all 30 cases. 5) The cases of "highly usefulness" and"fair usefulness"together were accounted for 67% of all studied cases. According to the results of the researches, we would conclude that Pranoprofen could be clinically safe and effective, when the agent was administered on cases postoperatively in the field of oral surgery expecting its anti-inflammatory efficacy.
日本歯科薬物療法学会の論文