Fundamental and clinical studies on Cefroxadine in the field of oral surgery.

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Fundamental and clinical studies in the field of oral surgery were carried out on Cefro-xadine (CXD) . The following results were obtained. 1) Antibacterial activity of CXD was compared with CCL, CEX and AMPC. Results show that it was similar or slightly superior to CEX and was slightly inferior to CCL. 2) The concentrations in serum and the oral tissues 60 minutes after administration of 500mg in fasting objects were 13.2+1.4μg/ml (mean ±S.E.) in serum, 65.1±1.2μg/ml (mean ±S.E.) in gingiva and 0.18μg/g in dental follicle. The mean serum concentration in non fasting objects were 0.25μg/ml at 30 min, 0.75μg/ml at 60 min, 5.3μg/ml at 90 min, 10.5μg/ml at 120 min, 6.34μg/ml at 240 min and 1.1μg/ml at 360 min. 3) Fifteen cases with oral infections were treated with 1, 500 mg Cefroxadine per day. Therapeutic responses were good in 12 cases, fair in 1 case and poor in 2 cases ; the efficacy rate was 80%. 4) Side effects associated with CXD were not noted except for 1 case of exanthema. 5) According to these results, CXD is considered to be a useful antibiotic for mild or moderate oral infections and for prevention of post operative infection.
日本歯科薬物療法学会の論文