Changes in pain tolerance thresholds with administration of an analgesic anti-inflammatory agent and anti-anxiety agent. Observation by the electric dental pulp tester.:Observation by the electric dental pulp tester

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With a purpose to observe the effect of analgesics and combination of an analgesic agent and an anti-anxiety agent, pain tolerance thresholds were evaluated by electrical teeth stimulation using an autoelectric dental pulp tester. The subjects were ten volunteered university students, including four males and six females, all in good health ages ranged from 20 to 22 years. As tested tooth, the healthy one was chosen from anterior teeth and molar teeth. Three kinds of drugs were administrated, an analgesic anti-inflammatory agent (prano-profen), the combination of pranoprofen and an anti-anxiety agent (clotiazepam), and placebo. Conclusion : Females showed the rises of thresholds for all the drugs including placebo, while males showed only for the real drugs, pranoprofen and the combination of prano-profen and clotiazepam. Compared with placebo, the rises of thresholds for pranoprofen and the combination of pranoprofen and clotiazepam were higher in males than in females. These observations suggested that autoelectric dental pulp tester was useful as an objective indicator for measuring pain tolerance thresholds. The observations also suggest that pre-administration of drugs, such as an anti-inflammatory agent and the combination of an anti-inflammatory agent and anti-anxiety agent, would be efficacious for raising patients' pain tolerance thresholds and comfort their pains in painfull dental treatment.
日本歯科薬物療法学会の論文