Clinical effects of dentifrices containing sodium chloride and anti-inflammatory agents on periodontal disease.
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概要
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The purpose of this study was to evaluate dentifrices containing sodium chloride and anti-inflammatory agents on the improvement of periodontal disease.<BR>Ninety four subjects which included patients with gingivitis or marginal periodontitis were divided into 3 groups: Group 1, Dentifrice containing 10% sodium chloride and 0.05% tranexamic acid (Dentifrice T<SUB>1</SUB>) ; Group 2, Dentifrice containing 10% sodium chloride, 0.03% ε-amino caproic acid and 0.05% dipostassium glycyrrhizinate (Dentifrice T<SUB>2</SUB>) ; Group 3, Dentifrice containing 9% sodium chloride, 0.03% ε-amino caproic acid and 0.03% aluminium chlorihydroxy allantoinate (Dentifrice T<SUB>3</SUB>) .<BR>Tooth-brushing was performed by all subjects twice a day for four weeks. The clinical observation was performed with respect to redness, swelling, bleeding, pus discharge and pocket depth.<BR>The results were summarized as follows:<BR>1) Dentifrice T<SUB>1</SUB>was significantly superior to dentifrice T<SUB>3</SUB>in the improvement of bleeding (<I>p</I><0.10) and pus discharge (<I>p</I><0.01) .<BR>2) Dentifrice T<SUB>2</SUB> was significantly superior to dentifrice T<SUB>3</SUB> in the improvement of pus discharge (<I>p</I><0.01) and pocket depth (<I>p</I><0.05) .<BR>3) Noparticular side effect was observed through this clinical study.
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