Fundamental and clinical studies of long acting amoxicillin granules (C-AMOX) in the infection in the field of oral and maxillofacial surgery.

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Long acting amoxicillin granules (C-AMOX), a newly developed presentation of amoxicillin (AMPC), maintains an effective blood level for an extended period. The following results were obtained from fundamental and clinical studies of C-AMOX.<BR>Serum and gingiva levels of AMPC were measured in 15 patients at 1, 2, 3, 4, and 6 (Patient 5) hours. Serum levels were 2. 34, 3. 07, 4. 23, 3.28μg/ml and 1.18μg/ml respectively, and gingiva levels were 0. 20, 0. 31, 0.54, 0.80μg/g and 0.15μg/g respectively.<BR>One-hundred and forty four patients with oral and maxillofacial infections containing maxillary or mandibular osteitis were treated with C-AMOX. Clinical efficacy was assessed according to the criteria of numerical judgement established by the Japanese Society of Oral Surgery (1973) and also by the global evaluation of the clinician. In numerical judgement there were 24 excellent cases, 82 good cases and 22 poor cases (efficacy ratio : 82.8 %) . The clinician's assessment was 22 excellent cases, 79 good cases, 30 fair cases and 4 poor cases (efficacy ratio: 74.8 %) .<BR>Although slight side effects, diarrhea, nausea, headache and flare of face were observed, both treatments were completed without problem. C-AMOX therapy (b. i, d.) showed good prolonged tissue levels and satisfactory clinical results.
日本歯科薬物療法学会の論文