Effect of tenidap on MMP-1 formation in nifedipine-reactive human gingival fibroblasts

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In our previous report, we demonstrated that tenidap, (±) -5-chloro-2, 3-dihydro-3- (hydroxy- 2-thienylmethylene) -2-oxo-1H-indole-1-carboxamide, decreased total collagen in cultured gingival fibroblasts. Since tenidap might be one of the choices for treating overgrown gingiva, it was interesting to clarify whether tenidap accelerates collagen degradation. Thus, we investigated the effect of tenidap on MMP-1 formation, ERK1/2 phosphorylation, and also the effect of MAPK inhibitor on MMP-1 mRNA expression induced by tenidap in human gingival fibroblasts originated from a nifedipine-reactive patient (NIFr) . Tenidap enhanced MMP-l formation, MMP-1 mRNA expression, and increased phospho-ERK1 and phospho-ERK2 in NIFr cells. Therefore, the decreased total collagen might be explained by the increased formation of MMP-1 in NIFr cells. Thus, we propose that tenidap could be considered as an agent for controlling gingival overgrowth.
日本歯科薬物療法学会の論文