Relationship between cAMP level and intracellular Ca2+ response elicited by histamine in human gingival fibroblasts

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The interaction between cAMP level and intracellular Ca2+ levels elicited by isoprenaline and histamine, respectively, in human gingival fibroblasts, NIFr (gingival fibroblasts originated from a nifedipine reactive patient; nifedipine responder) and NIFn (gingival fibroblasts originated from a nifedipine non-reactive patient; nifedipine non-responder) cells, was investigated. Intracellular Ca2+ level was increased by 1 mM histamine, where NIFr cells were more susceptible than NIFn cells. NIFr cells showed increased cAMP level by isoprenaline and the cAMP increase was inhibited by propranorol, indicating that gingival fibroblasts possess β-adrenergic receptors that activate adenylate cyclase. The increase of intracellular Ca2+ level elicited by histamine was depressed by isoprenaline, where NIFn cells responded more than NIFr cells.
日本歯科薬物療法学会の論文