Resistant recurrent aphthous stomatitis in an AIDS patient-Efficacy and problems of long-term corticosteroid therapy-:-Efficacy and problems of long-term corticosteroid therapy-

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Recurrent aphthous stomatitis (RAS) in HIV patients is treated by local application of corticosteroid or oral administration of 40-60 mg/day of prednisone or prednisolone for less than 14 days, as recommended by treatment guidelines. However, when the immune system does not improve, large aphthous stomatitis keeps recurring over a short period of time. We treated an AIDS patient with resistant RAS using long-term prednisolone therapy.<BR>The patient presented with hemophilia B complicated by AIDS. Aphthous stomatitis lesions were 10-15 mm in diameter. Aphthous stomatitis was unresponsive to corticosteroid ointment, but responded to oral administration of prednisolone 40 mg/day for 4-7 days. However, when the immune system became severely compromised, aphthous stomatitis kept recurring over a short period of time.<BR>As a result, 5 mg of prednisolone was administered every other day, and this was successful in suppressing recurrence without adverse effects.<BR>Long-term prednisolone therapy was useful in treating RAS when the immune system was severely compromised. In such treatment, close communication and teamwork is required between the physician and dentist to prevent adverse effects.
日本歯科薬物療法学会の論文